Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM53805
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
>59642±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM53805
Synonyms:
4-[(3E)-3-(6-chloranyl-2-oxidanylidene-4-phenyl-quinolin-3-ylidene)-5-(furan-2-yl)pyrazolidin-1-yl]-4-oxidanylidene-butanoic acid | 4-[(3E)-3-(6-chloro-2-keto-4-phenyl-3-quinolylidene)-5-(2-furyl)pyrazolidin-1-yl]-4-keto-butyric acid | 4-[(3E)-3-(6-chloro-2-oxo-4-phenyl-3-quinolinylidene)-5-(2-furanyl)-1-pyrazolidinyl]-4-oxobutanoic acid | 4-[(3E)-3-(6-chloro-2-oxo-4-phenylquinolin-3-ylidene)-5-(furan-2-yl)pyrazolidin-1-yl]-4-oxobutanoic acid | 4-[3-(6-Chloro-2-oxo-4-phenyl-1,2-dihydro-quinolin-3-yl)-5-furan-2-yl-4,5-dihydro-pyrazol-1-yl]-4-oxo-butyric acid | MLS000553742 | SMR000171762 | cid_5343329
Type:
Small organic molecule
Emp. Form.:
C26H20ClN3O5
Mol. Mass.:
489.907
SMILES:
OC(=O)CCC(=O)N1N=C(CC1c1ccco1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:8|
Structure:
Search PDB for entries with ligand similarity: