Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM61863
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide.
IC50
6080±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. PubChem Bioassay (2009)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM61863
Synonyms:
2-[(2,6-diketo-4,4-dimethyl-cyclohexyl)-(5-ethyl-4-nitro-2-thienyl)methyl]-5,5-dimethyl-cyclohexane-1,3-quinone | 2-[(4,4-dimethyl-2,6-dioxocyclohexyl)-(5-ethyl-4-nitro-2-thiophenyl)methyl]-5,5-dimethylcyclohexane-1,3-dione | 2-[(4,4-dimethyl-2,6-dioxocyclohexyl)-(5-ethyl-4-nitrothiophen-2-yl)methyl]-5,5-dimethylcyclohexane-1,3-dione | 2-[[4,4-dimethyl-2,6-bis(oxidanylidene)cyclohexyl]-(5-ethyl-4-nitro-thiophen-2-yl)methyl]-5,5-dimethyl-cyclohexane-1,3-dione | MLS000708681 | SMR000289248 | cid_1078769
Type:
Small organic molecule
Emp. Form.:
C23H29NO6S
Mol. Mass.:
447.544
SMILES:
CCc1sc(cc1[N+]([O-])=O)C(C1C(=O)CC(C)(C)CC1=O)C1C(=O)CC(C)(C)CC1=O
Structure:
Search PDB for entries with ligand similarity: