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Target
Bcl-2-like protein 1
Ligand
BDBM61855
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50
108803±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM61855
Synonyms:
(E)-2-(1,3-dithiolan-2-ylidene)-5-(2-furanyl)-3-oxo-4-pentenoic acid | (E)-2-(1,3-dithiolan-2-ylidene)-5-(2-furyl)-3-keto-pent-4-enoic acid | (E)-2-(1,3-dithiolan-2-ylidene)-5-(furan-2-yl)-3-oxidanylidene-pent-4-enoic acid | (E)-2-(1,3-dithiolan-2-ylidene)-5-(furan-2-yl)-3-oxopent-4-enoic acid | 2-(1,3-dithiolan-2-ylidene)-5-(2-furyl)-3-oxo-4-pentenoic acid | MLS000540779 | SMR000161795 | cid_708372
Type:
Small organic molecule
Emp. Form.:
C12H10O4S2
Mol. Mass.:
282.335
SMILES:
[#8]-[#6](=O)-[#6](\[#6](=O)\[#6]=[#6]\c1ccco1)=[#6]-1/[#16]-[#6]-[#6]-[#16]-1
Structure:
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