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Target
Bcl-2-like protein 1
Ligand
BDBM61864
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50
108803±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM61864
Synonyms:
3-({[(2E)-2-(2-hydroxy-3-methoxybenzylidene)hydrazino]carbonothioyl}amino)benzoic acid | 3-[[[(E)-(5-methoxy-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]amino]carbamothioylamino]benzoic acid | 3-[[[(E)-(5-methoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]carbamothioylamino]benzoic acid | 3-[[[(E)-(6-keto-5-methoxy-cyclohexa-2,4-dien-1-ylidene)methyl]amino]thiocarbamoylamino]benzoic acid | 3-[[[[(E)-(5-methoxy-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]hydrazo]-sulfanylidenemethyl]amino]benzoic acid | MLS000681698 | SMR000312742 | cid_6259353
Type:
Small organic molecule
Emp. Form.:
C16H15N3O4S
Mol. Mass.:
345.373
SMILES:
COc1cccc(C=NNC(=S)Nc2cccc(c2)C(O)=O)c1O |w:8.8|
Structure:
Search PDB for entries with ligand similarity: