Target
Bcl-2-like protein 1
Ligand
BDBM48888
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50
108803±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM48888
Synonyms:
(E)-3-(2-furanyl)-N,N-bis(2-pyridinyl)-2-propenamide | (E)-3-(2-furyl)-N,N-bis(2-pyridyl)acrylamide | (E)-3-(furan-2-yl)-N,N-dipyridin-2-yl-prop-2-enamide | (E)-3-(furan-2-yl)-N,N-dipyridin-2-ylprop-2-enamide | MLS001003781 | SMR000347602 | cid_5666777
Type:
Small organic molecule
Emp. Form.:
C17H13N3O2
Mol. Mass.:
291.304
SMILES:
O=C(\C=C\c1ccco1)N(c1ccccn1)c1ccccn1
Structure:
Search PDB for entries with ligand similarity: