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Target
Bcl-2-like protein 1
Ligand
BDBM61882
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50
108803±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM61882
Synonyms:
MLS001232805 | N-[(E)-1-[3-[(4-chlorobenzoyl)amino]phenyl]ethylideneamino]-2,5-dihydroxy-benzamide | N-[1-[3-[(4-chlorobenzoyl)amino]phenyl]ethylideneamino]-2,5-dihydroxy-benzamide | N-[1-[3-[(4-chlorobenzoyl)amino]phenyl]ethylideneamino]-2,5-dihydroxybenzamide | N-[1-[3-[(4-chlorophenyl)carbonylamino]phenyl]ethylideneamino]-2,5-bis(oxidanyl)benzamide | N-[1-[3-[[(4-chlorophenyl)-oxomethyl]amino]phenyl]ethylideneamino]-2,5-dihydroxybenzamide | SMR000679054 | cid_24818702
Type:
Small organic molecule
Emp. Form.:
C22H18ClN3O4
Mol. Mass.:
423.849
SMILES:
CC(=NNC(=O)c1cc(O)ccc1O)c1cccc(NC(=O)c2ccc(Cl)cc2)c1 |w:2.2|
Structure:
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