Reaction Details Report a problem with these data
Target
Bcl-2-like protein 1
Ligand
BDBM55000
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50
25257±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM55000
Synonyms:
(E)-N-[2-(2,6-difluoroanilino)-2-keto-ethyl]-N-ethyl-3-(2-quinolyl)acrylamide | (E)-N-[2-(2,6-difluoroanilino)-2-oxoethyl]-N-ethyl-3-(2-quinolinyl)-2-propenamide | (E)-N-[2-(2,6-difluoroanilino)-2-oxoethyl]-N-ethyl-3-quinolin-2-ylprop-2-enamide | (E)-N-[2-[[2,6-bis(fluoranyl)phenyl]amino]-2-oxidanylidene-ethyl]-N-ethyl-3-quinolin-2-yl-prop-2-enamide | MLS001128172 | SMR000713765 | cid_24979772
Type:
Small organic molecule
Emp. Form.:
C22H19F2N3O2
Mol. Mass.:
395.402
SMILES:
CCN(CC(=O)Nc1c(F)cccc1F)C(=O)\C=C\c1ccc2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: