Reaction Details Report a problem with these data
Target
Neuropeptides B/W receptor type 1
Ligand
BDBM62135
Substrate
n/a
Meas. Tech.
Fluorescence-based dose response cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7).
IC50
5862±n/a nM
Citation
 PubChem, PC Fluorescence-based dose response cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). PubChem Bioassay (2010)[AID] 
Target
Name:
Neuropeptides B/W receptor type 1
Synonyms:
GPR7 | NPBW1_HUMAN | NPBWR1 | neuropeptides B/W receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36111.82
Organism:
Homo sapiens (Human)
Description:
gi_119607128
Residue:
328
Sequence:
MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
  
Inhibitor
Name:
BDBM62135
Synonyms:
4-[[(E)-2-cyano-3-[4-(3-fluorobenzoyl)oxy-3-methoxy-phenyl]acryloyl]amino]benzoic acid | 4-[[(E)-2-cyano-3-[4-(3-fluorobenzoyl)oxy-3-methoxyphenyl]prop-2-enoyl]amino]benzoic acid | 4-[[(E)-2-cyano-3-[4-(3-fluorophenyl)carbonyloxy-3-methoxy-phenyl]prop-2-enoyl]amino]benzoic acid | 4-[[(E)-2-cyano-3-[4-[(3-fluorophenyl)-oxomethoxy]-3-methoxyphenyl]-1-oxoprop-2-enyl]amino]benzoic acid | MLS001181302 | SMR000502581 | cid_5810215
Type:
Small organic molecule
Emp. Form.:
C25H17FN2O6
Mol. Mass.:
460.4107
SMILES:
COc1cc(\C=C(/C#N)C(=O)Nc2ccc(cc2)C(O)=O)ccc1OC(=O)c1cccc(F)c1
Structure:
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