Reaction Details Report a problem with these data
Target
Neuropeptides B/W receptor type 1
Ligand
BDBM62157
Substrate
n/a
Meas. Tech.
Fluorescence-based dose response cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7).
IC50
43807±n/a nM
Citation
 PubChem, PC Fluorescence-based dose response cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). PubChem Bioassay (2010)[AID] 
Target
Name:
Neuropeptides B/W receptor type 1
Synonyms:
GPR7 | NPBW1_HUMAN | NPBWR1 | neuropeptides B/W receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36111.82
Organism:
Homo sapiens (Human)
Description:
gi_119607128
Residue:
328
Sequence:
MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
  
Inhibitor
Name:
BDBM62157
Synonyms:
MLS001221698 | N-[2-(cyclohexylamino)-2-keto-1-(4-pyridyl)ethyl]-N-(4-ethylphenyl)thiadiazole-4-carboxamide | N-[2-(cyclohexylamino)-2-oxidanylidene-1-pyridin-4-yl-ethyl]-N-(4-ethylphenyl)-1,2,3-thiadiazole-4-carboxamide | N-[2-(cyclohexylamino)-2-oxo-1-pyridin-4-ylethyl]-N-(4-ethylphenyl)-4-thiadiazolecarboxamide | N-[2-(cyclohexylamino)-2-oxo-1-pyridin-4-ylethyl]-N-(4-ethylphenyl)thiadiazole-4-carboxamide | SMR000601623 | [1,2,3]Thiadiazole-4-carboxylic acid (cyclohexylcarbamoyl-pyridin-4-yl-methyl)-(4-ethyl-phenyl)-amide | cid_3219293
Type:
Small organic molecule
Emp. Form.:
C24H27N5O2S
Mol. Mass.:
449.568
SMILES:
CCc1ccc(cc1)N(C(C(=O)NC1CCCCC1)c1ccncc1)C(=O)c1csnn1
Structure:
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