Target
Regulator of G-protein signaling 16
Ligand
BDBM62216
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao for SAR Compounds
Ki
1160±n/a nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao for SAR Compounds PubChem Bioassay (2010)[AID] 
Target
Name:
Regulator of G-protein signaling 16
Synonyms:
RGS16 | RGS16_HUMAN | RGSR | Regulator of G-protein signaling 16 (RGS16) | regulator of G-protein signalling 16
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22748.87
Organism:
Homo sapiens (Human)
Description:
gi_156416009
Residue:
202
Sequence:
MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEWGSKHSKENRNFSEDVLGWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEEFICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDLAAQASAASATLSSCSLDEPSHT
  
Inhibitor
Name:
BDBM62216
Synonyms:
2-(4,6-dimethylisothiazolo[5,4-b]pyridin-3-yl)oxy-1-[3-methyl-4-(m-tolyl)piperazino]ethanone | 2-[(4,6-dimethyl-3-isothiazolo[5,4-b]pyridinyl)oxy]-1-[3-methyl-4-(3-methylphenyl)-1-piperazinyl]ethanone | 2-[(4,6-dimethyl-[1,2]thiazolo[5,4-b]pyridin-3-yl)oxy]-1-[3-methyl-4-(3-methylphenyl)piperazin-1-yl]ethanone | KUC103347N | UNM-0000305811 | cid_25227363
Type:
Small organic molecule
Emp. Form.:
C22H26N4O2S
Mol. Mass.:
410.532
SMILES:
CC1CN(CCN1c1cccc(C)c1)C(=O)COc1nsc2nc(C)cc(C)c12
Structure:
Search PDB for entries with ligand similarity: