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Target
Tumor necrosis factor
Ligand
BDBM50100134
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction revised
IC50
762±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction revised PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM50100134
Synonyms:
2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiazol-3-ium | 2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiazol-3-ium(thioflavin T) | 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium | CHEMBL224392 | CHEMBL57267 | Thioflavin T | Thioflavin T, 1 | [4-(3,6-dimethyl-benzothiazol-2-yl)-phenyl]-dimethyl-amine | cid_16954
Type:
Small organic molecule
Emp. Form.:
C17H19N2S
Mol. Mass.:
283.411
SMILES:
CN(C)c1ccc(cc1)-c1sc2cc(C)ccc2[n+]1C
Structure:
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