Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM62228
Substrate
n/a
Meas. Tech.
Late stage counterscreen assay for S1P4 antagonists: Fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 2 (S1P2)
IC50
>25000±n/a nM
Citation
 PubChem, PC Late stage counterscreen assay for S1P4 antagonists: Fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 2 (S1P2) PubChem Bioassay (2010)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM62228
Synonyms:
(E)-N-(4-hydroxy-2-isopropyl-5-methyl-phenyl)-3-phenyl-acrylamide | (E)-N-(4-hydroxy-5-methyl-2-propan-2-ylphenyl)-3-phenyl-2-propenamide | (E)-N-(4-hydroxy-5-methyl-2-propan-2-ylphenyl)-3-phenylprop-2-enamide | (E)-N-(5-methyl-4-oxidanyl-2-propan-2-yl-phenyl)-3-phenyl-prop-2-enamide | SR-01000744962 | SR-01000744962-2 | cid_706322
Type:
Small organic molecule
Emp. Form.:
C19H21NO2
Mol. Mass.:
295.3755
SMILES:
CC(C)c1cc(O)c(C)cc1NC(=O)\C=C\c1ccccc1
Structure:
Search PDB for entries with ligand similarity: