Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM62620
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM62620
Synonyms:
5-[[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanylmethyl]furan-2-carboxylic acid | 5-[[[4-methyl-6-(trifluoromethyl)-2-pyrimidinyl]thio]methyl]-2-furancarboxylic acid | 5-[[[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]thio]methyl]-2-furoic acid | MLS000042797 | SMR000047980 | cid_666743
Type:
Small organic molecule
Emp. Form.:
C12H9F3N2O3S
Mol. Mass.:
318.272
SMILES:
Cc1cc(nc(SCc2ccc(o2)C(O)=O)n1)C(F)(F)F
Structure:
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