Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM62690
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM62690
Synonyms:
1-(4-methylphenyl)-3-(2-morpholin-4-yl-2-pyridin-3-yl-ethyl)urea | 1-(4-methylphenyl)-3-(2-morpholin-4-yl-2-pyridin-3-ylethyl)urea | 1-(4-methylphenyl)-3-[2-(4-morpholinyl)-2-(3-pyridinyl)ethyl]urea | 1-[2-morpholino-2-(3-pyridyl)ethyl]-3-(p-tolyl)urea | MLS000092202 | N-(4-methylphenyl)-N'-(2-morpholin-4-yl-2-pyridin-3-ylethyl)urea | SMR000027106 | cid_3241009
Type:
Small organic molecule
Emp. Form.:
C19H24N4O2
Mol. Mass.:
340.4195
SMILES:
Cc1ccc(NC(=O)NCC(N2CCOCC2)c2cccnc2)cc1
Structure:
Search PDB for entries with ligand similarity: