Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63369
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63369
Synonyms:
(2S)-6-amino-2-[4-[(1R)-1-amino-2-hydroxy-ethyl]triazol-1-yl]-1-piperazino-hexan-1-one;hydrochloride | (2S)-6-amino-2-[4-[(1R)-1-amino-2-hydroxyethyl]-1-triazolyl]-1-(1-piperazinyl)-1-hexanone;hydrochloride | (2S)-6-amino-2-[4-[(1R)-1-amino-2-hydroxyethyl]triazol-1-yl]-1-piperazin-1-ylhexan-1-one;hydrochloride | (2S)-6-azanyl-2-[4-[(1R)-1-azanyl-2-oxidanyl-ethyl]-1,2,3-triazol-1-yl]-1-piperazin-1-yl-hexan-1-one;hydrochloride | CD-MONO-SK-DP | MLS000560619 | SMR000327459 | cid_16129564
Type:
Small organic molecule
Emp. Form.:
C14H27N7O2
Mol. Mass.:
325.4099
SMILES:
NCCCC[C@@H](C(=O)N1CCNCC1)n1cc(nn1)[C@@H](N)CO
Structure:
Search PDB for entries with ligand similarity: