Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM48027
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
6726±1063 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM48027
Synonyms:
4-[[(4E)-1-keto-4-mesitylsulfonylimino-2-naphthyl]amino]benzoic acid | 4-[[(4E)-1-oxidanylidene-4-(2,4,6-trimethylphenyl)sulfonylimino-naphthalen-2-yl]amino]benzoic acid | 4-[[(4E)-1-oxo-4-(2,4,6-trimethylphenyl)sulfonylimino-2-naphthalenyl]amino]benzoic acid | 4-[[(4E)-1-oxo-4-(2,4,6-trimethylphenyl)sulfonyliminonaphthalen-2-yl]amino]benzoic acid | MLS000948031 | SMR000620244 | cid_9609431
Type:
Small organic molecule
Emp. Form.:
C26H22N2O5S
Mol. Mass.:
474.528
SMILES:
Cc1cc(C)c(c(C)c1)S(=O)(=O)N=C1C=C(Nc2ccc(cc2)C(O)=O)C(=O)c2ccccc12 |w:12.12,t:15|
Structure:
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