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Target
Serine/threonine-protein phosphatase
Ligand
BDBM64540
Substrate
n/a
Meas. Tech.
Luminesence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin
EC50
180000±n/a nM
Citation
 PubChem, PC Luminesence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin PubChem Bioassay (2010)[AID] 
Target
Name:
Serine/threonine-protein phosphatase
Synonyms:
calcineurin A1, putative | calmodulin-binding protein 1, putative | serine/threonine-protein phosphatase 2B catalytic subunit A1, putative
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69558.03
Organism:
Candida dubliniensis CD36
Description:
gi_223640082
Residue:
607
Sequence:
MSGNTVQRNTEQINNALNAIQHRRTTTGNDLNHTNQRIISQNSINDKDYTIYITDDGEKYSTVERAVKSVDPPVTFKPKDEQVFLSNGKPNHQFLKQHFIHEGRLHEHQAIQILKQATHLLSKESNLLNVPAPVTICGDVHGQYYDLMKLFEVGGDPATTKYLFLGDYVDRGSFSIECLLYLYSLKINYPDTFWMLRGNHECRHLTEYFTFKNECLHKYSEQLYEECLVSFNALPLAAIMNEQFFCVHGGLSPQLTSLDSLRKLHRFREPPTKGLMCDLLWADPIEEYDEDNIDQEYVTNVVRGCSFAFTYKAACKFLDKTKLLSVIRAHEAQNAGYRMYKRTKTMGFPSLLTMFSAPNYLDSYNNKAAVLKYENNVMNIRQFNASPHPYWLPHFMDVFTWSLPFVGEKVTDMLVSILNVCTEEELDEDLPFSESEIGVATKTTKTTTPVSPVSPKAHPPSTRITSPYKSTKLVESDNNPNTNNDDSEMTLEEKKQALRNKIIAIGKMSRMFQVLREEQENVAHLKELNRGSLPKGSLLHGVDGLKNTINSFEEAKAADRINEALPPSPEDIQRLKQEKNTRIRQQIENQEMSGPVFQRLIRRLSQS
  
Inhibitor
Name:
BDBM64540
Synonyms:
4-[4-[(E)-3-phenylprop-2-enyl]-1-piperazinyl]benzofuro[3,2-d]pyrimidine | 4-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]-[1]benzofuro[3,2-d]pyrimidine | 4-[4-[(E)-cinnamyl]piperazino]benzofuro[3,2-d]pyrimidine | MLS000041560 | SMR000044666 | cid_2012115
Type:
Small organic molecule
Emp. Form.:
C23H22N4O
Mol. Mass.:
370.447
SMILES:
C(\C=C\c1ccccc1)N1CCN(CC1)c1ncnc2c3ccccc3oc12
Structure:
Search PDB for entries with ligand similarity: