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Target
Serine/threonine-protein phosphatase
Ligand
BDBM64546
Substrate
n/a
Meas. Tech.
Luminesence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin
EC50
180000±n/a nM
Citation
 PubChem, PC Luminesence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin PubChem Bioassay (2010)[AID] 
Target
Name:
Serine/threonine-protein phosphatase
Synonyms:
calcineurin A1, putative | calmodulin-binding protein 1, putative | serine/threonine-protein phosphatase 2B catalytic subunit A1, putative
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69558.03
Organism:
Candida dubliniensis CD36
Description:
gi_223640082
Residue:
607
Sequence:
MSGNTVQRNTEQINNALNAIQHRRTTTGNDLNHTNQRIISQNSINDKDYTIYITDDGEKYSTVERAVKSVDPPVTFKPKDEQVFLSNGKPNHQFLKQHFIHEGRLHEHQAIQILKQATHLLSKESNLLNVPAPVTICGDVHGQYYDLMKLFEVGGDPATTKYLFLGDYVDRGSFSIECLLYLYSLKINYPDTFWMLRGNHECRHLTEYFTFKNECLHKYSEQLYEECLVSFNALPLAAIMNEQFFCVHGGLSPQLTSLDSLRKLHRFREPPTKGLMCDLLWADPIEEYDEDNIDQEYVTNVVRGCSFAFTYKAACKFLDKTKLLSVIRAHEAQNAGYRMYKRTKTMGFPSLLTMFSAPNYLDSYNNKAAVLKYENNVMNIRQFNASPHPYWLPHFMDVFTWSLPFVGEKVTDMLVSILNVCTEEELDEDLPFSESEIGVATKTTKTTTPVSPVSPKAHPPSTRITSPYKSTKLVESDNNPNTNNDDSEMTLEEKKQALRNKIIAIGKMSRMFQVLREEQENVAHLKELNRGSLPKGSLLHGVDGLKNTINSFEEAKAADRINEALPPSPEDIQRLKQEKNTRIRQQIENQEMSGPVFQRLIRRLSQS
  
Inhibitor
Name:
BDBM64546
Synonyms:
4-ethyl-3-(2-methyl-5-thiophen-2-yl-thieno[2,3-d]pyrimidin-4-yl)sulfanyl-1H-1,2,4-triazol-5-one | 4-ethyl-3-(2-methyl-5-thiophen-2-ylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1H-1,2,4-triazol-5-one | 4-ethyl-3-[(2-methyl-5-thiophen-2-yl-4-thieno[2,3-d]pyrimidinyl)thio]-1H-1,2,4-triazol-5-one | 4-ethyl-3-[[2-methyl-5-(2-thienyl)thieno[2,3-d]pyrimidin-4-yl]thio]-1H-1,2,4-triazol-5-one | MLS000056329 | SMR000068446 | cid_2559955
Type:
Small organic molecule
Emp. Form.:
C15H13N5OS3
Mol. Mass.:
375.492
SMILES:
CCn1c(Sc2nc(C)nc3scc(-c4cccs4)c23)n[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: