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Target
Tumor necrosis factor
Ligand
BDBM54221
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
1932±497 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54221
Synonyms:
MLS000581648 | N-[4-(1,3-benzothiazol-2-yl)benzyl]-2-methoxy-benzamide | N-[4-(1,3-benzothiazol-2-yl)benzyl]-2-methoxybenzamide | N-[[4-(1,3-benzothiazol-2-yl)phenyl]methyl]-2-methoxy-benzamide | N-[[4-(1,3-benzothiazol-2-yl)phenyl]methyl]-2-methoxybenzamide | SMR000200576 | cid_979773
Type:
Small organic molecule
Emp. Form.:
C22H18N2O2S
Mol. Mass.:
374.456
SMILES:
COc1ccccc1C(=O)NCc1ccc(cc1)-c1nc2ccccc2s1
Structure:
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