Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM54254
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
1628±144.5 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54254
Synonyms:
(E)-2-(1H-benzimidazol-2-yl)-3-(3-chlorophenyl)-1-phenyl-2-propen-1-one | (E)-2-(1H-benzimidazol-2-yl)-3-(3-chlorophenyl)-1-phenyl-prop-2-en-1-one | (E)-2-(1H-benzimidazol-2-yl)-3-(3-chlorophenyl)-1-phenylprop-2-en-1-one | MLS000390145 | SMR000259409 | cid_6122140
Type:
Small organic molecule
Emp. Form.:
C22H15ClN2O
Mol. Mass.:
358.82
SMILES:
Clc1cccc(\C=C(\C(=O)c2ccccc2)c2nc3ccccc3[nH]2)c1
Structure:
Search PDB for entries with ligand similarity: