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Target
Tumor necrosis factor
Ligand
BDBM57710
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
1161±607 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM57710
Synonyms:
4-[(5-methyl-2-propan-2-yl-phenoxy)methyl]-N'-[(E)-(5-oxidanyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]benzohydrazide | MLS000408882 | N'-[(E)-(5-hydroxy-6-keto-cyclohexa-2,4-dien-1-ylidene)methyl]-4-[(2-isopropyl-5-methyl-phenoxy)methyl]benzohydrazide | N'-[(E)-(5-hydroxy-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-4-[(5-methyl-2-propan-2-ylphenoxy)methyl]benzohydrazide | N'-[(E)-(5-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[(5-methyl-2-propan-2-ylphenoxy)methyl]benzohydrazide | SMR000243095 | cid_15945423
Type:
Small organic molecule
Emp. Form.:
C25H26N2O4
Mol. Mass.:
418.4849
SMILES:
CC(C)c1ccc(C)cc1OCc1ccc(cc1)C(=O)NN=Cc1cccc(O)c1O |w:21.22|
Structure:
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