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Target
Tumor necrosis factor
Ligand
BDBM54366
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
1836.5±146.5 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54366
Synonyms:
(6E)-3-benzoxy-6-[4-(4-methoxyphenyl)-3-pyrazolin-3-ylidene]cyclohexa-2,4-dien-1-one | (6E)-6-[4-(4-methoxyphenyl)-1,2-dihydropyrazol-3-ylidene]-3-phenylmethoxy-1-cyclohexa-2,4-dienone | (6E)-6-[4-(4-methoxyphenyl)-1,2-dihydropyrazol-3-ylidene]-3-phenylmethoxy-cyclohexa-2,4-dien-1-one | (6E)-6-[4-(4-methoxyphenyl)-1,2-dihydropyrazol-3-ylidene]-3-phenylmethoxycyclohexa-2,4-dien-1-one | 5-Benzyloxy-2-[4-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-phenol | MLS000778889 | SMR000415582 | cid_16681768
Type:
Small organic molecule
Emp. Form.:
C23H20N2O3
Mol. Mass.:
372.4165
SMILES:
COc1ccc(cc1)-c1c[nH]nc1-c1ccc(OCc2ccccc2)cc1O
Structure:
Search PDB for entries with ligand similarity: