Target
Kappa-type opioid receptor
Ligand
BDBM65832
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 2
EC50
>20000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM65832
Synonyms:
KSC-5-177 | KUC103856N | N-[2-(cyclohexylamino)-2-keto-ethyl]-N-(2-thenyl)picolinamide | N-[2-(cyclohexylamino)-2-oxidanylidene-ethyl]-N-(thiophen-2-ylmethyl)pyridine-2-carboxamide | N-[2-(cyclohexylamino)-2-oxoethyl]-N-(thiophen-2-ylmethyl)-2-pyridinecarboxamide | N-[2-(cyclohexylamino)-2-oxoethyl]-N-(thiophen-2-ylmethyl)pyridine-2-carboxamide | cid_1458208
Type:
Small organic molecule
Emp. Form.:
C19H23N3O2S
Mol. Mass.:
357.47
SMILES:
O=C(CN(Cc1cccs1)C(=O)c1ccccn1)NC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: