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Target
NADPH oxidase 1
Ligand
BDBM65837
Substrate
n/a
Meas. Tech.
Late stage results from the probe development effort to identify inhibitors of NOX1: HEK/293 IC50
IC50
1810±n/a nM
Citation
 PubChem, PC Late stage results from the probe development effort to identify inhibitors of NOX1: HEK/293 IC50 PubChem Bioassay (2010)[AID] 
Target
Name:
NADPH oxidase 1
Synonyms:
MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN
Type:
PROTEIN
Mol. Mass.:
64890.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792877
Residue:
564
Sequence:
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
  
Inhibitor
Name:
BDBM65837
Synonyms:
4-(4,5-diphenyl-1,3-dihydroimidazol-2-ylidene)-2-methoxy-1-cyclohexa-2,5-dienone | 4-(4,5-diphenyl-1,3-dihydroimidazol-2-ylidene)-2-methoxy-cyclohexa-2,5-dien-1-one | 4-(4,5-diphenyl-1,3-dihydroimidazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one | 4-(4,5-diphenyl-4-imidazolin-2-ylidene)-2-methoxy-cyclohexa-2,5-dien-1-one | SR-01000442018-2 | cid_5337430
Type:
Small organic molecule
Emp. Form.:
C22H18N2O2
Mol. Mass.:
342.3905
SMILES:
COc1cc(ccc1O)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Structure:
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