Reaction Details Report a problem with these data
Target
NADPH oxidase 1
Ligand
BDBM65851
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1)
IC50
4570±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1) PubChem Bioassay (2010)[AID] 
Target
Name:
NADPH oxidase 1
Synonyms:
MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN
Type:
PROTEIN
Mol. Mass.:
64890.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792877
Residue:
564
Sequence:
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
  
Inhibitor
Name:
BDBM65851
Synonyms:
1-(10-phenothiazinyl)ethanone | 1-phenothiazin-10-ylethanone | SR-01000809845 | SR-01000809845-2 | cid_74200
Type:
Small organic molecule
Emp. Form.:
C14H11NOS
Mol. Mass.:
241.308
SMILES:
CC(=O)N1c2ccccc2Sc2ccccc12
Structure:
Search PDB for entries with ligand similarity: