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Target
Inward rectifier potassium channel 2
Ligand
BDBM65856
Substrate
n/a
Meas. Tech.
Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1
IC50
35587±25325 nM
Citation
 PubChem, PC Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 PubChem Bioassay (2010)[AID] 
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Irk1 | KCNJ2_MOUSE | Kcnj2 | inward rectifier potassium channel 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48383.35
Organism:
Mus musculus
Description:
gi_6680530
Residue:
428
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
  
Inhibitor
Name:
BDBM65856
Synonyms:
3-chloranyl-4-(1-ethylbenzimidazol-2-yl)sulfanyl-aniline | 3-chloro-4-(1-ethylbenzimidazol-2-yl)sulfanylaniline | 3-chloro-4-[(1-ethyl-1H-benzimidazol-2-yl)thio]aniline | 3-chloro-4-[(1-ethyl-2-benzimidazolyl)thio]aniline | MLS000050654 | SMR000078102 | [3-chloro-4-[(1-ethylbenzimidazol-2-yl)thio]phenyl]amine | cid_973685
Type:
Small organic molecule
Emp. Form.:
C15H14ClN3S
Mol. Mass.:
303.81
SMILES:
CCn1c(Sc2ccc(N)cc2Cl)nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: