Reaction Details Report a problem with these data
Target
Inward rectifier potassium channel 2
Ligand
BDBM65873
Substrate
n/a
Meas. Tech.
Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1
IC50
34673±18738 nM
Citation
 PubChem, PC Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 PubChem Bioassay (2010)[AID] 
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Irk1 | KCNJ2_MOUSE | Kcnj2 | inward rectifier potassium channel 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48383.35
Organism:
Mus musculus
Description:
gi_6680530
Residue:
428
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
  
Inhibitor
Name:
BDBM65873
Synonyms:
(3-bromo-4-methoxy-benzyl)-homopiperonyl-amine;oxalic acid | 2-(1,3-benzodioxol-5-yl)-N-[(3-bromanyl-4-methoxy-phenyl)methyl]ethanamine;ethanedioic acid | 2-(1,3-benzodioxol-5-yl)-N-[(3-bromo-4-methoxyphenyl)methyl]ethanamine;oxalic acid | MLS001197115 | N-[2-(1,3-benzodioxol-5-yl)ethyl]-N-(3-bromo-4-methoxybenzyl)amine | SMR000555601 | cid_17367790
Type:
Small organic molecule
Emp. Form.:
C17H18BrNO3
Mol. Mass.:
364.234
SMILES:
COc1ccc(CNCCc2ccc3OCOc3c2)cc1Br
Structure:
Search PDB for entries with ligand similarity: