Reaction Details Report a problem with these data
Target
Inward rectifier potassium channel 2
Ligand
BDBM65874
Substrate
n/a
Meas. Tech.
Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1
IC50
21477±3516 nM
Citation
 PubChem, PC Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 PubChem Bioassay (2010)[AID] 
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Irk1 | KCNJ2_MOUSE | Kcnj2 | inward rectifier potassium channel 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48383.35
Organism:
Mus musculus
Description:
gi_6680530
Residue:
428
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
  
Inhibitor
Name:
BDBM65874
Synonyms:
2-[[2-[(2-hydroxy-5-methyl-benzyl)amino]ethylamino]methyl]-4-methyl-phenol | 2-[[2-[(2-hydroxy-5-methylphenyl)methylamino]ethylamino]methyl]-4-methylphenol | 4-methyl-2-[[2-[(5-methyl-2-oxidanyl-phenyl)methylamino]ethylamino]methyl]phenol | MLS001242795 | SMR000841359 | cid_3627083
Type:
Small organic molecule
Emp. Form.:
C18H24N2O2
Mol. Mass.:
300.3954
SMILES:
Cc1ccc(O)c(CNCCNCc2cc(C)ccc2O)c1
Structure:
Search PDB for entries with ligand similarity: