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Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM65903
Substrate
n/a
Meas. Tech.
Mode of action assay-Automated electrophysiology assay of compounds that potentiate KCNQ2 potassium channel
EC50
920±190 nM
Citation
 PubChem, PC Mode of action assay-Automated electrophysiology assay of compounds that potentiate KCNQ2 potassium channel PubChem Bioassay (2010)[AID] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
  
Inhibitor
Name:
BDBM65903
Synonyms:
4-butyl-N-[2-(2-furanyl)-2-(4-morpholinyl)ethyl]-1-cyclohexanecarboxamide | 4-butyl-N-[2-(2-furyl)-2-morpholino-ethyl]cyclohexanecarboxamide | 4-butyl-N-[2-(furan-2-yl)-2-morpholin-4-yl-ethyl]cyclohexane-1-carboxamide | 4-butyl-N-[2-(furan-2-yl)-2-morpholin-4-ylethyl]cyclohexane-1-carboxamide | MLS001157981 | SMR000651419 | cid_16445308
Type:
Small organic molecule
Emp. Form.:
C21H34N2O3
Mol. Mass.:
362.5063
SMILES:
CCCCC1CCC(CC1)C(=O)NCC(N1CCOCC1)c1ccco1 |(3.08,-8.12,;4.41,-7.34,;4.41,-5.8,;5.75,-5.03,;5.75,-3.49,;7.08,-2.72,;7.08,-1.18,;5.75,-.41,;4.41,-1.18,;4.41,-2.72,;5.75,1.13,;4.41,1.9,;7.08,1.9,;7.08,3.44,;8.41,4.21,;9.75,3.44,;11.08,4.21,;12.42,3.44,;12.42,1.9,;11.08,1.13,;9.75,1.9,;8.41,5.75,;9.66,6.65,;9.18,8.12,;7.64,8.12,;7.17,6.65,)|
Structure:
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