Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM65950
Substrate
n/a
Meas. Tech.
Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel
EC50
12400±3750 nM
Citation
 PubChem, PC Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel PubChem Bioassay (2011)[AID] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
  
Inhibitor
Name:
BDBM65950
Synonyms:
1-(3-fluorophenyl)-3-(5-methyl-3-pyridinyl)urea;2,2,2-trifluoroacetic acid | 1-(3-fluorophenyl)-3-(5-methyl-3-pyridyl)urea;2,2,2-trifluoroacetic acid | 1-(3-fluorophenyl)-3-(5-methylpyridin-3-yl)urea;2,2,2-trifluoroacetic acid | 1-(3-fluorophenyl)-3-(5-methylpyridin-3-yl)urea;2,2,2-tris(fluoranyl)ethanoic acid | VU0417943-1 | cid_45489579
Type:
Small organic molecule
Emp. Form.:
C13H12FN3O
Mol. Mass.:
245.2523
SMILES:
Cc1cncc(NC(=O)Nc2cccc(F)c2)c1
Structure:
Search PDB for entries with ligand similarity: