Reaction Details Report a problem with these data
Target
60S ribosomal protein L19-A
Ligand
BDBM57650
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically RPL19A based on MLPCN hits
EC50
4019±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically RPL19A based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
60S ribosomal protein L19-A
Synonyms:
RL19A_YEAST | RPL19A | RPL23A | YL14A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21739.62
Organism:
Saccharomyces cerevisiae
Description:
gi_536029
Residue:
189
Sequence:
MANLRTQKRLAASVVGVGKRKVWLDPNETSEIAQANSRNAIRKLVKNGTIVKKAVTVHSKSRTRAHAQSKREGRHSGYGKRKGTREARLPSQVVWIRRLRVLRRLLAKYRDAGKIDKHLYHVLYKESKGNAFKHKRALVEHIIQAKADAQREKALNEEAEARRLKNRAARDRRAQRVAEKRDALLKEDA
  
Inhibitor
Name:
BDBM57650
Synonyms:
5-[2,5-bis(oxidanylidene)pyrrol-1-yl]-N-(3-chloranyl-4-methyl-phenyl)-2-morpholin-4-yl-benzamide | MLS000678894 | N-(3-chloro-4-methyl-phenyl)-5-maleimido-2-morpholino-benzamide | N-(3-chloro-4-methylphenyl)-5-(2,5-dioxo-1-pyrrolyl)-2-(4-morpholinyl)benzamide | N-(3-chloro-4-methylphenyl)-5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-(4-morpholinyl)benzamide | N-(3-chloro-4-methylphenyl)-5-(2,5-dioxopyrrol-1-yl)-2-morpholin-4-ylbenzamide | SMR000269962 | cid_1335691
Type:
Small organic molecule
Emp. Form.:
C22H20ClN3O4
Mol. Mass.:
425.865
SMILES:
Cc1ccc(NC(=O)c2cc(ccc2N2CCOCC2)N2C(=O)C=CC2=O)cc1Cl |c:25|
Structure:
Search PDB for entries with ligand similarity: