Reaction Details Report a problem with these data
Target
60S ribosomal protein L19-A
Ligand
BDBM66002
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically RPL19A based on MLPCN hits
EC50
8029±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically RPL19A based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
60S ribosomal protein L19-A
Synonyms:
RL19A_YEAST | RPL19A | RPL23A | YL14A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21739.62
Organism:
Saccharomyces cerevisiae
Description:
gi_536029
Residue:
189
Sequence:
MANLRTQKRLAASVVGVGKRKVWLDPNETSEIAQANSRNAIRKLVKNGTIVKKAVTVHSKSRTRAHAQSKREGRHSGYGKRKGTREARLPSQVVWIRRLRVLRRLLAKYRDAGKIDKHLYHVLYKESKGNAFKHKRALVEHIIQAKADAQREKALNEEAEARRLKNRAARDRRAQRVAEKRDALLKEDA
  
Inhibitor
Name:
BDBM66002
Synonyms:
4-({5-[(2,6-difluorophenoxy)methyl]isoxazol-3-yl}carbonyl)-1-methyl-2-phenylpiperazine | MLS000734617 | SMR000317833 | [5-[(2,6-difluorophenoxy)methyl]-1,2-oxazol-3-yl]-(4-methyl-3-phenylpiperazin-1-yl)methanone | [5-[(2,6-difluorophenoxy)methyl]-3-isoxazolyl]-(4-methyl-3-phenyl-1-piperazinyl)methanone | [5-[(2,6-difluorophenoxy)methyl]isoxazol-3-yl]-(4-methyl-3-phenyl-piperazino)methanone | [5-[[2,6-bis(fluoranyl)phenoxy]methyl]-1,2-oxazol-3-yl]-(4-methyl-3-phenyl-piperazin-1-yl)methanone | cid_16188379
Type:
Small organic molecule
Emp. Form.:
C22H21F2N3O3
Mol. Mass.:
413.4172
SMILES:
CN1CCN(CC1c1ccccc1)C(=O)c1cc(COc2c(F)cccc2F)on1
Structure:
Search PDB for entries with ligand similarity: