Reaction Details Report a problem with these data
Target
60S ribosomal protein L19-A
Ligand
BDBM63893
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically RPL19A based on MLPCN hits
EC50
13000±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically RPL19A based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
60S ribosomal protein L19-A
Synonyms:
RL19A_YEAST | RPL19A | RPL23A | YL14A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21739.62
Organism:
Saccharomyces cerevisiae
Description:
gi_536029
Residue:
189
Sequence:
MANLRTQKRLAASVVGVGKRKVWLDPNETSEIAQANSRNAIRKLVKNGTIVKKAVTVHSKSRTRAHAQSKREGRHSGYGKRKGTREARLPSQVVWIRRLRVLRRLLAKYRDAGKIDKHLYHVLYKESKGNAFKHKRALVEHIIQAKADAQREKALNEEAEARRLKNRAARDRRAQRVAEKRDALLKEDA
  
Inhibitor
Name:
BDBM63893
Synonyms:
4-(tert-butyl)-N'-[(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy]benzenecarboximidamide | 4-tert-butyl-N''-(1-methylpyrazolo[3,4-d]pyrimidin-4-yl)oxy-benzenecarboximidamide | 4-tert-butyl-N''-(1-methylpyrazolo[3,4-d]pyrimidin-4-yl)oxybenzenecarboximidamide | 4-tert-butyl-N''-[(1-methyl-4-pyrazolo[3,4-d]pyrimidinyl)oxy]benzenecarboximidamide | 4-tert-butyl-N'-(1-methylpyrazolo[3,4-d]pyrimidin-4-yl)oxy-benzamidine | MLS001111236 | SMR000457996 | cid_2809015
Type:
Small organic molecule
Emp. Form.:
C17H20N6O
Mol. Mass.:
324.3803
SMILES:
Cn1ncc2c(ON=C(N)c3ccc(cc3)C(C)(C)C)ncnc12 |w:7.6|
Structure:
Search PDB for entries with ligand similarity: