Reaction Details Report a problem with these data
Target
General amino acid permease AGP1
Ligand
BDBM65986
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically AGP1 based on MLPCN hits
EC50
2807±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically AGP1 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
General amino acid permease AGP1
Synonyms:
AGP1 | AGP1_YEAST | Agp1p
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69674.09
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_85666113
Residue:
633
Sequence:
MSSSKSLYELKDLKNSSTEIHATGQDNEIEYFETGSNDRPSSQPHLGYEQHNTSAVRRFFDSFKRADQGPQDEVEATQMNDLTSAISPSSRQAQELEKNESSDNIGANTGHKSDSLKKTIQPRHVLMIALGTGIGTGLLVGNGTALVHAGPAGLLIGYAIMGSILYCIIQACGEMALVYSNLTGGYNAYPSFLVDDGFGFAVAWVYCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVIIFYVLVITINIFGARGYAEAEFFFNCCKILMMTGFFILGIIIDVGGAGNDGFIGGKYWHDPGAFNGKHAIDRFKGVAATLVTAAFAFGGSEFIAITTAEQSNPRKAIPGAAKQMIYRILFLFLATIILLGFLVPYNSDQLLGSTGGGTKASPYVIAVASHGVRVVPHFINAVILLSVLSMANSSFYSSARLFLTLSEQGYAPKVFSYIDRAGRPLIAMGVSALFAVIAFCAASPKEEQVFTWLLAISGLSQLFTWTAICLSHLRFRRAMKVQGRSLGELGFKSQTGVWGSAYACIMMILILIAQFWVAIAPIGEGKLDAQAFFENYLAMPILIALYVGYKVWHKDWKLFIRADKIDLDSHRQIFDEELIKQEDEEYRERLRNGPYWKRVVAFWC
  
Inhibitor
Name:
BDBM65986
Synonyms:
2-(3-bromophenyl)-4-quinolinecarboxylic acid [2-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-2-oxoethyl] ester | 2-(3-bromophenyl)cinchoninic acid [2-[4-(2-furoyl)piperazino]-2-keto-ethyl] ester | MLS000564139 | SMR000151689 | [2-[4-(furan-2-carbonyl)piperazin-1-yl]-2-oxoethyl] 2-(3-bromophenyl)quinoline-4-carboxylate | [2-[4-(furan-2-ylcarbonyl)piperazin-1-yl]-2-oxidanylidene-ethyl] 2-(3-bromophenyl)quinoline-4-carboxylate | cid_2391688
Type:
Small organic molecule
Emp. Form.:
C27H22BrN3O5
Mol. Mass.:
548.385
SMILES:
Brc1cccc(c1)-c1cc(C(=O)OCC(=O)N2CCN(CC2)C(=O)c2ccco2)c2ccccc2n1
Structure:
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