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Target
Vacuolar aminopeptidase 1
Ligand
BDBM44877
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits
EC50
11690±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Vacuolar aminopeptidase 1
Synonyms:
AMPL_YEAST | APE1 | API | LAP4 | YSC1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57084.90
Organism:
Saccharomyces cerevisiae
Description:
gi_486173
Residue:
514
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
  
Inhibitor
Name:
BDBM44877
Synonyms:
2-Cyano-2-[(2,4-dimethyl-phenyl)-hydrazono]-thioacetamide | 2-amino-N-(2,4-dimethylanilino)-2-sulfanylideneethanimidoyl cyanide | 2-cyano-2-[(2,4-dimethylphenyl)hydrazinylidene]ethanethioamide | 2-cyano-2-[(2,4-dimethylphenyl)hydrazono]thioacetamide | MLS000554383 | SMR000146700 | cid_915258
Type:
Small organic molecule
Emp. Form.:
C11H12N4S
Mol. Mass.:
232.305
SMILES:
Cc1ccc(NN=C(C#N)C(N)=S)c(C)c1 |w:6.5|
Structure:
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