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Target
Vacuolar aminopeptidase 1
Ligand
BDBM65992
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits
EC50
2236±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Vacuolar aminopeptidase 1
Synonyms:
AMPL_YEAST | APE1 | API | LAP4 | YSC1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57084.90
Organism:
Saccharomyces cerevisiae
Description:
gi_486173
Residue:
514
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
  
Inhibitor
Name:
BDBM65992
Synonyms:
(E)-3-(1-methyl-3-indolyl)-2-nitro-2-propenoic acid ethyl ester | (E)-3-(1-methylindol-3-yl)-2-nitro-acrylic acid ethyl ester | 3-(1-Methyl-1H-indol-3-yl)-2-nitro-acrylic acid ethyl ester | MLS000564480 | SMR000174261 | cid_1951180 | ethyl (E)-3-(1-methylindol-3-yl)-2-nitro-prop-2-enoate | ethyl (E)-3-(1-methylindol-3-yl)-2-nitroprop-2-enoate
Type:
Small organic molecule
Emp. Form.:
C14H14N2O4
Mol. Mass.:
274.272
SMILES:
CCOC(=O)C(=C/c1cn(C)c2ccccc12)\[N+]([O-])=O
Structure:
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