Reaction Details Report a problem with these data
Target
Vacuolar aminopeptidase 1
Ligand
BDBM66052
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits
EC50
6302±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Vacuolar aminopeptidase 1
Synonyms:
AMPL_YEAST | APE1 | API | LAP4 | YSC1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57084.90
Organism:
Saccharomyces cerevisiae
Description:
gi_486173
Residue:
514
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
  
Inhibitor
Name:
BDBM66052
Synonyms:
(6E)-6-[[2-[3-chloranyl-5-(trifluoromethyl)pyridin-2-yl]hydrazinyl]methylidene]-2-methoxy-cyclohexa-2,4-dien-1-one | (6E)-6-[[2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazinyl]methylidene]-2-methoxycyclohexa-2,4-dien-1-one | (6E)-6-[[N'-[3-chloro-5-(trifluoromethyl)-2-pyridyl]hydrazino]methylene]-2-methoxy-cyclohexa-2,4-dien-1-one | (6E)-6-[[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]hydrazo]methylidene]-2-methoxy-1-cyclohexa-2,4-dienone | 2-hydroxy-3-methoxybenzaldehyde [3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazone | MLS000586497 | SMR000207876 | cid_5795723
Type:
Small organic molecule
Emp. Form.:
C14H11ClF3N3O2
Mol. Mass.:
345.704
SMILES:
COc1cccc(CN=Nc2ncc(cc2Cl)C(F)(F)F)c1O |w:9.9|
Structure:
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