Reaction Details Report a problem with these data
Target
Vacuolar aminopeptidase 1
Ligand
BDBM64688
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits
EC50
2550±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Vacuolar aminopeptidase 1
Synonyms:
AMPL_YEAST | APE1 | API | LAP4 | YSC1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57084.90
Organism:
Saccharomyces cerevisiae
Description:
gi_486173
Residue:
514
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
  
Inhibitor
Name:
BDBM64688
Synonyms:
5-bromanyl-2-pyridin-2-yl-6-(trifluoromethyl)-1H-pyrimidin-4-one | 5-bromo-2-(2-pyridinyl)-6-(trifluoromethyl)-1H-pyrimidin-4-one | 5-bromo-2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinol | 5-bromo-2-(2-pyridyl)-6-(trifluoromethyl)-1H-pyrimidin-4-one | 5-bromo-2-pyridin-2-yl-6-(trifluoromethyl)-1H-pyrimidin-4-one | MLS000736006 | SMR000338556 | cid_1478662
Type:
Small organic molecule
Emp. Form.:
C10H5BrF3N3O
Mol. Mass.:
320.065
SMILES:
FC(F)(F)c1nc([nH]c(=O)c1Br)-c1ccccn1
Structure:
Search PDB for entries with ligand similarity: