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Target
Vacuolar aminopeptidase 1
Ligand
BDBM66083
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits
EC50
762±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Vacuolar aminopeptidase 1
Synonyms:
AMPL_YEAST | APE1 | API | LAP4 | YSC1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57084.90
Organism:
Saccharomyces cerevisiae
Description:
gi_486173
Residue:
514
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
  
Inhibitor
Name:
BDBM66083
Synonyms:
4-Bromo-benzoic acid N'-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-quinoline-3-carbonyl)-hydrazide | MLS001218817 | N'-(4-bromobenzoyl)-2-hydroxy-1-methyl-4-oxoquinoline-3-carbohydrazide | N'-(4-bromobenzoyl)-2-hydroxy-4-keto-1-methyl-quinoline-3-carbohydrazide | N'-(4-bromophenyl)carbonyl-1-methyl-2-oxidanyl-4-oxidanylidene-quinoline-3-carbohydrazide | N'-[(4-bromophenyl)-oxomethyl]-2-hydroxy-1-methyl-4-oxo-3-quinolinecarbohydrazide | SMR000608073 | cid_1087418
Type:
Small organic molecule
Emp. Form.:
C18H14BrN3O4
Mol. Mass.:
416.225
SMILES:
Cn1c2ccccc2c(O)c(C(=O)NNC(=O)c2ccc(Br)cc2)c1=O
Structure:
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