Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM47600
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase
IC50
8450±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase PubChem Bioassay (2010)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM47600
Synonyms:
(E)-1-(4-bromophenyl)-3-[4-(diethylamino)phenyl]-2-propen-1-one | (E)-1-(4-bromophenyl)-3-[4-(diethylamino)phenyl]prop-2-en-1-one | MLS000416450 | SMR000264251 | cid_5379238
Type:
Small organic molecule
Emp. Form.:
C19H20BrNO
Mol. Mass.:
358.272
SMILES:
CCN(CC)c1ccc(\C=C\C(=O)c2ccc(Br)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: