Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM53126
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase
IC50
19116±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase PubChem Bioassay (2010)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM53126
Synonyms:
2-(4-Chloro-phenyl)-6-hydroxy-benzo[de]isoquinoline-1,3-dione | 2-(4-chlorophenyl)-6-hydroxy-benzo[de]isoquinoline-1,3-quinone | 2-(4-chlorophenyl)-6-hydroxybenzo[de]isoquinoline-1,3-dione | 2-(4-chlorophenyl)-6-oxidanyl-benzo[de]isoquinoline-1,3-dione | MLS001204988 | SMR000515419 | cid_5396293
Type:
Small organic molecule
Emp. Form.:
C18H10ClNO3
Mol. Mass.:
323.73
SMILES:
Oc1ccc2C(=O)N(C(=O)c3cccc1c23)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: