Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM61733
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput counterscreen to identify inhibitors of TEM-1 metallo-beta-lactamase
IC50
>59640±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput counterscreen to identify inhibitors of TEM-1 metallo-beta-lactamase PubChem Bioassay (2010)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29494.42
Organism:
Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67
Description:
gi_60115532
Residue:
269
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTDGESGNYG
  
Inhibitor
Name:
BDBM61733
Synonyms:
2-chloranyl-5-[2-[(1-propan-2-ylindol-3-yl)methylidene]hydrazinyl]benzoic acid | 2-chloro-5-[2-[(1-propan-2-yl-3-indolyl)methylidene]hydrazinyl]benzoic acid | 2-chloro-5-[2-[(1-propan-2-ylindol-3-yl)methylidene]hydrazinyl]benzoic acid | 2-chloro-5-[N'-[(1-isopropylindol-3-yl)methylene]hydrazino]benzoic acid | MLS001183676 | SMR000502846 | cid_4373715
Type:
Small organic molecule
Emp. Form.:
C19H18ClN3O2
Mol. Mass.:
355.818
SMILES:
CC(C)n1cc(CN=Nc2ccc(Cl)c(c2)C(O)=O)c2ccccc12 |w:7.6|
Structure:
Search PDB for entries with ligand similarity: