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Target
Beta-lactamase
Ligand
BDBM66130
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase
IC50
13660±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase PubChem Bioassay (2010)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM66130
Synonyms:
MLS001212969 | N-[4-(6-Hydroxy-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-phenyl]-acetamide | N-[4-(6-hydroxy-1,3-diketo-benzo[de]isoquinolin-2-yl)phenyl]acetamide | N-[4-(6-hydroxy-1,3-dioxo-2-benzo[de]isoquinolinyl)phenyl]acetamide | N-[4-(6-hydroxy-1,3-dioxobenzo[de]isoquinolin-2-yl)phenyl]acetamide | N-[4-[6-oxidanyl-1,3-bis(oxidanylidene)benzo[de]isoquinolin-2-yl]phenyl]ethanamide | SMR000515418 | cid_5406244
Type:
Small organic molecule
Emp. Form.:
C20H14N2O4
Mol. Mass.:
346.3362
SMILES:
CC(=O)Nc1ccc(cc1)N1C(=O)c2cccc3c(O)ccc(C1=O)c23
Structure:
Search PDB for entries with ligand similarity: