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Target
Beta-lactamase
Ligand
BDBM66136
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase
IC50
8620±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase PubChem Bioassay (2010)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM66136
Synonyms:
2-amino-5-(3-hydroxy-6-keto-xanthen-9-yl)benzoic acid | 2-amino-5-(3-hydroxy-6-oxo-9-xanthenyl)benzoic acid | 2-amino-5-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid | 2-azanyl-5-(3-oxidanyl-6-oxidanylidene-xanthen-9-yl)benzoic acid | MLS001216583 | SMR000544115 | cid_3801816
Type:
Small organic molecule
Emp. Form.:
C20H13NO5
Mol. Mass.:
347.3209
SMILES:
Nc1ccc(cc1C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12
Structure:
Search PDB for entries with ligand similarity: