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Target
Beta-lactamase
Ligand
BDBM66148
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase
IC50
10938±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase PubChem Bioassay (2010)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM66148
Synonyms:
MLS001224570 | N-[(E)-1-[4-(p-anisoylamino)phenyl]ethylideneamino]isonicotinamide | N-[1-[4-(p-anisoylamino)phenyl]ethylideneamino]isonicotinamide | N-[1-[4-[(4-methoxybenzoyl)amino]phenyl]ethylideneamino]pyridine-4-carboxamide | N-[1-[4-[(4-methoxyphenyl)carbonylamino]phenyl]ethylideneamino]pyridine-4-carboxamide | N-[1-[4-[[(4-methoxyphenyl)-oxomethyl]amino]phenyl]ethylideneamino]-4-pyridinecarboxamide | SMR000679031 | cid_4299664
Type:
Small organic molecule
Emp. Form.:
C22H20N4O3
Mol. Mass.:
388.4192
SMILES:
COc1ccc(cc1)C(=O)Nc1ccc(cc1)C(C)=NNC(=O)c1ccncc1 |w:19.21|
Structure:
Search PDB for entries with ligand similarity: