Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM47203
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)
IC50
>39841±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM47203
Synonyms:
3-(1-benzofuran-2-carbonyl)-2-(3-bromophenyl)-1-[2-(dimethylamino)ethyl]-4-hydroxy-2H-pyrrol-5-one | 3-(1-benzofuran-2-ylcarbonyl)-2-(3-bromophenyl)-1-[2-(dimethylamino)ethyl]-4-oxidanyl-2H-pyrrol-5-one | 3-[2-benzofuranyl(oxo)methyl]-2-(3-bromophenyl)-1-[2-(dimethylamino)ethyl]-4-hydroxy-2H-pyrrol-5-one | 4-(Benzofuran-2-carbonyl)-5-(3-bromo-phenyl)-1-(2-dimethylamino-ethyl)-3-hydroxy-1,5-dihydro-pyrrol- 2-one | 4-(benzofuran-2-carbonyl)-5-(3-bromophenyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-3-pyrrolin-2-one | MLS000556936 | SMR000148053 | cid_3564285
Type:
Small organic molecule
Emp. Form.:
C23H21BrN2O4
Mol. Mass.:
469.328
SMILES:
CN(C)CCN1C(C(C(=O)c2cc3ccccc3o2)C(=O)C1=O)c1cccc(Br)c1
Structure:
Search PDB for entries with ligand similarity: