Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM66174
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)
IC50
>39841±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM66174
Synonyms:
2-(methylthio)-4-oxo-6-phenyl-1H-pyrimidine-5-carbonitrile | 2-methylsulfanyl-4-oxidanylidene-6-phenyl-1H-pyrimidine-5-carbonitrile | 2-methylsulfanyl-4-oxo-6-phenyl-1H-pyrimidine-5-carbonitrile | 4-hydroxy-2-(methylsulfanyl)-6-phenyl-5-pyrimidinecarbonitrile | 4-keto-2-(methylthio)-6-phenyl-1H-pyrimidine-5-carbonitrile | MLS000544838 | SMR000126595 | cid_389655
Type:
Small organic molecule
Emp. Form.:
C12H9N3OS
Mol. Mass.:
243.284
SMILES:
CSc1nc(-c2ccccc2)c(C#N)c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: