Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM66183
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)
IC50
2039±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM66183
Synonyms:
1-(4,6-dimethyl-2-pyridinyl)-3-(3-methoxyphenyl)thiourea | 1-(4,6-dimethyl-2-pyridyl)-3-(3-methoxyphenyl)thiourea | 1-(4,6-dimethylpyridin-2-yl)-3-(3-methoxyphenyl)thiourea | MLS000861730 | N-(4,6-dimethyl-2-pyridinyl)-N'-(3-methoxyphenyl)thiourea | SMR000460514 | cid_2731492
Type:
Small organic molecule
Emp. Form.:
C15H17N3OS
Mol. Mass.:
287.38
SMILES:
COc1cccc(NC(=S)Nc2cc(C)cc(C)n2)c1
Structure:
Search PDB for entries with ligand similarity: