Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM66191
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)
IC50
>39841±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM66191
Synonyms:
1-(6-Bromo-4-phenyl-quinazolin-2-yl)-piperidine-4-carboxylic acid | 1-(6-bromanyl-4-phenyl-quinazolin-2-yl)piperidine-4-carboxylic acid | 1-(6-bromo-4-phenyl-2-quinazolinyl)-4-piperidinecarboxylic acid | 1-(6-bromo-4-phenyl-quinazolin-2-yl)isonipecotic acid | 1-(6-bromo-4-phenylquinazolin-2-yl)piperidine-4-carboxylic acid | MLS001197028 | SMR000555694 | cid_1145396
Type:
Small organic molecule
Emp. Form.:
C20H18BrN3O2
Mol. Mass.:
412.28
SMILES:
OC(=O)C1CCN(CC1)c1nc(-c2ccccc2)c2cc(Br)ccc2n1
Structure:
Search PDB for entries with ligand similarity: