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Target
Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1)
Ligand
BDBM66159
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)
IC50
2728±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3): TR-FRET-based biochemical high throughput dose response assay to identify agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) PubChem Bioassay (2010)[AID] 
Target
Name:
Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1)
Synonyms:
CTG26 | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2 (TRAC-1) | nuclear receptor corepressor 2 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81401.89
Organism:
Homo sapiens (Human)
Description:
Q9Y618-2 gi_116256445
Residue:
766
Sequence:
MAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKALMGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE
  
Inhibitor
Name:
BDBM66159
Synonyms:
3-(1-benzofuran-2-carbonyl)-1-(furan-2-ylmethyl)-4-hydroxy-2-pyridin-3-yl-2H-pyrrol-5-one | 3-(1-benzofuran-2-ylcarbonyl)-1-(furan-2-ylmethyl)-4-oxidanyl-2-pyridin-3-yl-2H-pyrrol-5-one | 3-[2-benzofuranyl(oxo)methyl]-1-(2-furanylmethyl)-4-hydroxy-2-(3-pyridinyl)-2H-pyrrol-5-one | 4-(1-benzofuran-2-ylcarbonyl)-1-(2-furylmethyl)-3-hydroxy-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one | 4-(benzofuran-2-carbonyl)-1-(2-furfuryl)-3-hydroxy-5-(3-pyridyl)-3-pyrrolin-2-one | MLS000099453 | SMR000074051 | cid_2944910
Type:
Small organic molecule
Emp. Form.:
C23H16N2O5
Mol. Mass.:
400.3835
SMILES:
O=C(C1C(N(Cc2ccco2)C(=O)C1=O)c1cccnc1)c1cc2ccccc2o1
Structure:
Search PDB for entries with ligand similarity: